Resveratrol is an AMPK activator and a Sirtuin activator which means it aids cellular homeostasis and stabilizes or “greases the wheels” of the epigenome. It has antioxidant effects, is well tolerated orally, and has very low toxicity. Plants naturally make Resveratrol to fight the harmful effects of UV radiation, stress, and injury. Plants with high concentrations of Resveratrol are grapes, peanuts, blueberries, cranberries, and cocoa. Grapes are the most well-known for providing this nature identical bioactive element. The use of grapes as a medicinal goes back many centuries and they are described in Hindu books as a tonic for the heart.
Resveratrol is hypothesized to be the reason that the French population has been spared certain conditions despite having a high smoking rate and high consumption of fats and coffee.
Heart and Blood Vessels
Resveratrol participates in several mechanisms that have direct effects on the cellular mechanisms in the genome and the epigenome of the heart muscle cells. Resveratrol also promotes normal blood flow and may also have beneficial effects on maintaining small blood vessel linings.
Resveratrol crosses the blood-brain barrier and has been found to prevent the accumulation of beta-amyloid plaques. Although more time is needed to study this effect, there does appear to be an added benefit in preventing these types of plaques in the brain and central nervous system to promote normal cognition
Resveratrol functions as a powerful antioxidant. Antioxidants help prevent cell damage caused by free radicals. Free radicals are unstable atoms caused by pollution, sunlight and our body’s metabolic pathways for the natural burning of fat. Free radicals can accelerate aging. Resveratrol helps eliminate these free radicals and works as an antioxidant synergistically with its stabilizing effects on the genome and epigenome to provide favorable characteristics for longevity. Resveratrol is considered one of the best free radical scavengers.
Resveratrol is a phytochemical that the grape skin manufactures to protect the grape from harmful UV radiation and other environmental sources. We are simply using this natural bioactive element for our own benefit. The grape, through its own evolutionary pathway, synthesizes Resveratrol for its own survival benefit. Maybe one day through our own evolutionary pathways we will also synthesize Resveratrol, but until then, we should take what the grape is giving us.
Resveratrol is one of the five natural bioactive elements to make up Rebesana. Like the other natural elements, Resveratrol has impressive qualities for promoting longevity. Understanding how Resveratrol affects the genome, epigenome and the Sirtuins, directly and indirectly, is the key. Research continues to reveal the mechanisms.
The dosing of Resveratrol can be tricky because different doses are associated with different effects as well. There is a fair amount of published information regarding the pharmacokinetics of oral Resveratrol. This includes oral ingestion and first-pass metabolism. What is known is that lower doses appear to be more favorable towards longevity and protection of the heart.
The oral ingestion of Resveratrol through its natural sources alone is not enough to cause the beneficial effects of Resveratrol on longevity. The equivalent amount of Resveratrol used in studies would require consuming 111 glasses of wine daily. So, you can see that although Resveratrol can be obtained naturally through wine, it is not possible to ingest the amounts of wine required to see the desired benefits we are looking for. What is needed is to amplify the amount of Resveratrol that you can ingest to up-regulate the beneficial effects on the cellular mechanisms that are associated with longevity. This is what is being done in all the studies that have occurred and that are underway.
Resveratrol is the fourth natural bioactive element that we have selected to be included in REBESANA. Nothing should be more important than extending our biological clock and promoting a longer, healthier, athletic life. This is one thing you should do for yourself. We hope that this information will help you make an educated life choice and begin using REBESANA on a daily basis. This should be the one thing you do for yourself.
Again, to review, NMN functions on the epigenome by raising NAD+ levels. Quercetin helps to eliminate senescent cells and also raises NAD+ levels. Berberine works to increase AMPK, decrease mTOR, and increase NAD+ as well as work on an enzymatic level to minimize oxidative stress, promote mitochondrial function and, by activating the cellular energy master switch, further grease the cell’s ability to function efficiently. Resveratrol works at the level of the epigenome by activating AMPK and Sirtuins, as well as through extracellular mechanisms. I previously referred to an invisible purposeful dance that occurs in our cells - a dance without smoke, flames or fanfare, but a beautiful dance that is so remarkably capable of promoting a healthy and more athletic life. All of these components function as molecular messengers to nudge these longevity genes (Sirtuins, AMPK and mTOR) in our favor. Hopefully, you can now see the big picture regarding why these natural bioactive elements have been included in Rebesana. These natural bioactive elements work as molecular messengers towards synergistically promoting longevity.