Senescence
Senescence is the deterioration of cells with age. It is the process in which a cell loses its power to divide or maintain itself. On an individual cellular/tissue level, when cellular senescence occurs, aging occurs.
Longevity
Longevity is promoted if a mother cell could always make an exact replica daughter cell through mitosis.
A mother cell cannot make an exact replica daughter cell without mitosis or if the epigenome identity is lost. If a cell cannot maintain itself or make an exact replica of itself, aging occurs. Each time a cell replicates, the opportunity door opens for a cell to lose its identity. A constant tenacious struggle occurs in each cell to maintain itself through mechanisms that naturally exist in the cell.
When we look at the small things in the cell to see what is occurring, what we see is that the epigenome identity is lost and the telomere is shortening. We will explain what the telomere is in a future issue. The mother cell, instead of
replacing itself with an exact replica daughter cell, either dies off or instead, converts itself into a senescent cell. This senescent cell now takes up the space that a normal cell would take up and this senescent cell also secretes irritating proteins that affect the neighboring cells.
So, the fabric of tissues that was once consistent and uniform is now interspersed with senescent cells. Our “silky” uniform layer of skin cells is now a patchwork of normal and senescent cells and voilà, we have disclosed one of the contributions to aged skin or wrinkles. This is easily seen on the skin but this is what is occurring in all of our tissues that age: tendons, joints, muscles, heart, brain, etc. We focus on what we can see, the skin, but all tissues and organ systems would look “wrinkly” if you could see inside your body. Skin wrinkles are a simple example of the human body growing older and accumulating senescent cells.
Quercetin
Quercetin is a senolytic natural compound found in capers, grapes, berries, cherries, apples, citrus, fruits, buckwheat, broccoli, kale, red onions, tomatoes, wine and black tea.
There is substantial science showing that Quercetin eliminates senolytic cells, and yes, we want to eliminate them if we can, not just for our skin but for all of our tissues and organs. Eliminating the senolytic cells eliminates the irritating proteins they secrete and eliminating the senolytic cells allows the neighboring cells to again have a chance to replicate normally and maintain our tissue as a uniform layer of “silk” instead of a “patchwork” of bumps, furrows, age spots and aged tissue.
Quercetin is a nature identical bioactive molecule that has been studied extensively and the benefits of Quercetin are fairly well established. It has been shown to increase the lifespan in mice, slow aging in tissues and effectively eliminate senolytic cells.
Longevity
Do not think of wrinkles as just a vanity issue — think of them as an example of what is occurring throughout your entire body — aging! The senescent cells continue to accumulate as we get older — causing us to age. Don’t forget that the senescent cells are not completely dormant. Not only do the senescent cells accumulate with time, but they also affect surrounding normal cells in a way by continuing to secrete proteins that contribute to aging in all tissues and organs that those cell lines make up.
This is Not a Vanity Issue
This is a Longevity Issue
Ideally, we want to eliminate the senescent cells. Removal of senescent cells has been shown to increase the lifespan in mouse models. The accumulation of senescent cells in humans is associated with aging. Removal of senescent cells in humans has been shown to be theoretically and clinically advantageous. Studies looking at the benefits of senolytics are ongoing and yield favorable early results.
Although we may all want to encounter a “Benjamin Button '' experience and reverse our biological clock, in reality, this nature identical bioactive molecule will hopefully slow the aging process, but not reverse or eliminate aging. Quercetin has also been found to be most effective when started early when the senescent cells are just starting to appear.
The extracellular matrix (ECM) consists of proteins, molecules, collagen, and elastin, and gives structure to tissues in the body. The ECM provides the medium in which cells reside and participates in how cells communicate with each other for cell growth and other cell functions. The irritating proteins that the senescent cells secrete affect the neighboring cells as well as the extracellular matrix. Quercetin is also an antioxidant and stimulates the mitochondria. So, when senescent cells do develop, Quercetin helps to eliminate them.
Quercetin has also found its way into many specialties in medicine where usage has been found to maintain certain tissues in the body. These anti-aging characteristics may promote the maintenance of tissues throughout the body and slow the aging process.
Amplification
The oral ingestion of Quercetin through its natural sources alone is not enough to activate the beneficial effects of Quercetin. What is required is to amplify the amount of Quercetin that you can ingest to up-regulate its beneficial effects on longevity. This is what is being done in all of the studies that have occurred and that are underway.
Quercetin is one of our five natural bioactive elements that we have selected to be in Rebesana. Quercetin is also anticipated to have synergistic and additive effects when combined with Resveratrol, which is also included in Rebesana. Nothing should be more important than extending our biological clock and promoting a healthier, more athletic life. We hope that this information will help you make an educated life choice and begin using Rebesana on a daily basis. This should be the one thing you do for yourself.
