NMN (Nicotinamide mononucleotide)
As we age our NAD+ levels and our AMPK levels decline. These are two proteins that are critical to maintaining normal cellular tissue and organ function. Components in Rebesana have been shown to increase both of these levels in our cells, tissues and organs. These proteins function to maintain the identity and specialization of our cells. NMN and Resveratrol in Rebesana also promote: an increase in oxidative metabolism, improve insulin sensitivity, boost mitochondrial function, promote recycling of misfolded proteins that accumulate and “gum up the works in our cells.” Potential benefits of maintaining NAD+ levels exist in the brain, heart, blood vessels, liver, muscle, pancreas, bone and immune function, all to promote longevity and a healthy life. NMN may also increase skin moisture, elasticity, and firmness, decrease the formation of wrinkles and maintain hair quality.
The Berberine in Rebesana functions to modulate our longevity genes in our favor, maintain the correct epigenetic on-off switches, promote cellular maintenance, cognition and function as an antioxidant. Berberine also functions to promote the recycling of misfolded proteins, function as a hypoglycemic and maintain other metabolic levels.
Resveratrol functions as an AMPK activator and a Sirtuin activator. It promotes the maintenance of the epigenome with similar maintenance effects on blood vessels, blood flow and the heart muscle. Resveratrol also crosses the blood-brain barrier and functions throughout the body as an antioxidant.
The Quercetin in Rebesana is also a senolytic that can function to eliminate senescent cells (cells that lose their ability to divide but remain and take up space in your tissues). As cells lose their identity and their specialization, they excrete irritating proteins that are detrimental to the function of tissues and organs. Senescent cells accumulate in all tissues and organs including tendons, muscles, ligaments, cartilage, bones, discs in the spine, cardiac muscle, vasculature, kidney, brain, liver, skin, etc. Accumulation of senescent cells is not desired. Studies looking at the benefits of senolytics yield favorable early results. Although senolytic compounds find their way into the media regarding their ability to possibly slow down the onset of skin wrinkles, recognize that the same wrinkles you see on your skin are essentially the same wrinkles that you can’t see but you are experiencing in all tissues in your body. Yes, we want to eliminate senescent cells. This is expected to be most effective when started early before a lot of senescent cells accumulate.
The telomeres are the protective tips of your DNA. These protective tips on your DNA naturally shorten with each cell division. The Astragalus in Rebesana has been found to function as an “on switch” for an enzyme, telomerase, to theoretically maintain the length of our telomeres. As the telomere naturally shortens, your cells will stop replicating or will enter into a dormant, “zombie” or senescent state. Encouraging the length of the telomere is vital in order to maintain the genome in specific cells. Some cells in your body, such as in the skin, the gastrointestinal system and the lung undergo a lot of mitoses. This is how cells replace themselves. When cells can no longer replace themselves through mitosis because the telomeres are too short, you start to age. When a mother cell can no longer replace itself with a daughter cell, that mother cell can die off or become a senescent cell. With each cellular division, your telomeres naturally shorten. Maintaining the length of your telomere goes a long way toward promoting longevity.
Yes, we have to look at the small things in the cell to see how we can persuade our cells to work better and for longer. Over the last 15 years, many publications have identified these small cellular processes and how we can orchestrate them in our favor.